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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SF3B1 All Species: 17.27
Human Site: T203 Identified Species: 31.67
UniProt: O75533 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75533 NP_036565.2 1304 145830 T203 R K R R W D Q T A D Q T P G A
Chimpanzee Pan troglodytes XP_516006 1379 153963 T278 R K R R W D Q T A D Q T P G A
Rhesus Macaque Macaca mulatta XP_001086317 1397 156322 T296 R K R R W D Q T A D Q T P G A
Dog Lupus familis XP_857149 1312 146628 T211 A D Q T P G A T P K K L S S W
Cat Felis silvestris
Mouse Mus musculus Q99NB9 1304 145798 T203 R K R R W D Q T A D Q T P G A
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_421912 1383 154834 Q282 K R K R R W D Q T A D Q T P G
Frog Xenopus laevis O57683 1307 146196 D206 R R W D Q T G D Q T P G S T P
Zebra Danio Brachydanio rerio XP_684311 1315 147162 T214 D Q T P S N S T P K K V S S W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623732 1315 147662 W197 A P K K R G R W D Q T D D A P
Nematode Worm Caenorhab. elegans NP_497853 1322 147305 D196 E K K K G R W D A E A P S T D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002323970 1267 141858 N176 D K G E K E S N S M A K R R N
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201232 1269 141432 S175 A A K H Q K D S A P P P P A S
Baker's Yeast Sacchar. cerevisiae P49955 971 110009
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.5 93.3 99.3 N.A. 99.9 N.A. N.A. N.A. 93.7 96.6 93.7 N.A. N.A. 82.4 65.1 N.A.
Protein Similarity: 100 94.5 93.3 99.3 N.A. 100 N.A. N.A. N.A. 93.7 98.3 96.4 N.A. N.A. 88.9 76.6 N.A.
P-Site Identity: 100 100 100 6.6 N.A. 100 N.A. N.A. N.A. 6.6 6.6 6.6 N.A. N.A. 0 13.3 N.A.
P-Site Similarity: 100 100 100 20 N.A. 100 N.A. N.A. N.A. 26.6 13.3 26.6 N.A. N.A. 20 33.3 N.A.
Percent
Protein Identity: 68.4 N.A. N.A. 68.3 40.4 N.A.
Protein Similarity: 79.3 N.A. N.A. 79.1 53.1 N.A.
P-Site Identity: 6.6 N.A. N.A. 13.3 0 N.A.
P-Site Similarity: 20 N.A. N.A. 33.3 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 24 8 0 0 0 0 8 0 47 8 16 0 0 16 31 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 16 8 0 8 0 31 16 16 8 31 8 8 8 0 8 % D
% Glu: 8 0 0 8 0 8 0 0 0 8 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 8 0 8 16 8 0 0 0 0 8 0 31 8 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 47 31 16 8 8 0 0 0 16 16 8 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 8 % N
% Pro: 0 8 0 8 8 0 0 0 16 8 16 16 39 8 16 % P
% Gln: 0 8 8 0 16 0 31 8 8 8 31 8 0 0 0 % Q
% Arg: 39 16 31 39 16 8 8 0 0 0 0 0 8 8 0 % R
% Ser: 0 0 0 0 8 0 16 8 8 0 0 0 31 16 8 % S
% Thr: 0 0 8 8 0 8 0 47 8 8 8 31 8 16 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % V
% Trp: 0 0 8 0 31 8 8 8 0 0 0 0 0 0 16 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _